Investigation of the effect of electroconvulsive treatment on serum glial cell line-derived neurotrophic factor levels in patients with schizophrenia and bipolar disorder

Objective: A relationship between glial cell line-derived neurotrophic factor (GDNF) and the etiology of schizophrenia (SCH) bipolar disorder (BD) has been reported. GDNF, in addition to other factors, may play a role mechanism action electroconvulsive treatment (ECT). The primary objective this study was investigate effect ECT on serum GDNF levels before after administration ECT. Method: Thirty male inpatients undergoing for SCH (n=20) or BD (n=10) 28 age- sex-matched healthy control subjects were included study. patients measured both using commercially available enzyme-linked immunosorbent assay kits. Results: with (p=0.013) but not (p=0.998) showed statistically significant change mean level all (SCH BD) significantly different from prior (p=0.177). Conclusion: current is first report comparison BD. findings do support hypothesis definitive outcomes SCH, such